Various pathways play a key role in the onset and progression of osteoarthritis, including Wnt/β-catenin, transforming growth factor β (TGF-β), bone morphogenic protein (BMP), fibroblast growth factor (FGF) signaling, nuclear factor κB (NF-κB) pathway, transient receptor potential vanilloid 1 (TRPV1) pathway, and RANK/RANKL/OPG pathway. This evidence concerns the gene TNFSF11 and osteoarthritis.