The curcumin-ameliorating effects in patients with knee osteoarthritis symptoms could mediated by modulating NLRP3 inflammasome and its constituents that can effectively maintain the balance between osteoclastogenesis and osteoblastogenesis, reducing NLRP3-mediated inflammation oxidative stress and possibly improving osteoarthritis pathophysiology as shown in Figure 2. Here, NLRP3 is linked to osteoarthritis, knee.