NLRP3 and osteoarthritis: The curcumin-ameliorating effects in patients with knee osteoarthritis symptoms could mediated by modulating NLRP3 inflammasome and its constituents that can effectively maintain the balance between osteoclastogenesis and osteoblastogenesis, reducing NLRP3-mediated inflammation oxidative stress and possibly improving osteoarthritis pathophysiology as shown in Figure 2.