Our group has previously identified circulating immune cell profiles in thyroiditis caused by immune checkpoint inhibitors (ICIs) (22), as well as healthy and other malignancy patients (23, 24); and more immune activator T cell subpopulations in the thyroid glands of patients developing PD-1/PD-L1 inhibitor-induced thyroiditis (25). The gene discussed is CD274; the disease is thyroid gland disorder.