Moreover, cytokine IL-10 inhibits the expression of Class II major histocompatibility complex (MHC) proteins (HLA-DR, HLA-DMA, and HLA-DMB) on the surface of macrophages and monocytes, which in addition to TGF-β, suppresses T-cell proliferation, contributing to immunosuppression in sepsis. This evidence concerns the gene TGFB1 and Sepsis.