Our finding that S100A8, S100A9, and IL10 promoters were hypomethylated in EPIC850K arrays at early stages of sepsis and septic shock (IL10 and S100A8 hypomethylation were also validated by pyrosequencing in the independent cohort) therefore suggested that these immunosuppression events occur concomitantly with the early cytokine storm. This evidence concerns the gene S100A8 and Sepsis.