Remarkably, when exposed to whole NLRC5+ cell lysates, PBMCs, splenocytes, and ascites cells obtained from NLRC5-overexpressing tumors were capable of strongly producing IFN-γ; even PBMCs from tumor-naïve mice showed T-cell activation potentially detecting naturally occurring self-antigens, which could be reflecting low-affinity T-cell clones (61). This evidence concerns the gene NLRC5 and neoplasm.