Circulating T cells displayed a stronger activation profile compared with those from parental tumors, and importantly, IFN-γ production was significantly induced when PBMCs, splenocytes, and ascites-derived cells from ID8-p53−/−NLRC5+ tumor-bearing mice were exposed to TAAs from NLRC5+ tumor cells, emphasizing a greater ability to increase the production and recognition of naturally occurring TAAs. The gene discussed is NLRC5; the disease is neoplasm.