Total expression of Eomes and T-bet transcription factors were significantly increased only in the T cells derived from NLRC5+ (C5) tumor-bearing mice (Figure 6F; Supplementary Figure 7D) underlining an increased T-cell effector potency, absent in T cells derived from the parental ID8-p53−/− (F3) tumor-bearing mice. The gene discussed is NLRC5; the disease is neoplasm.