IFN-γ production was also significantly enhanced in splenocytes and ascites derived from ID8-p53−/−NLRC5+ tumor-bearing mice even in the presence of Ag irrMC38 (derived from MC38), once more emphasizing autologous reactivity against self-shared peptides also generated by this colorectal cancer cell line (Figure 6H). The gene discussed is TP53; the disease is neoplasm.