Figures 6A–D displays the soluble levels of the vascular injury markers (CRP, SAA, sVCAM-1 and s-ICAM-1) in the supernatants obtained following the incubation of HUVECs with PLT-EXOs derived from various study groups. As compared to healthy controls, the levels of all the four vascular injury markers were significantly higher in the dengue patients (CRP, SAA and sVCAM-1: p<0.0001 and sICAM-1: p=0.0002). Notably, a significantly higher expression levels were observed in the SDG than WS- patient groups for CRP and SAA (p=0.035); and sVCAM1 (p=0.006) respectively (Figures 6A–C). The gene discussed is ICAM1; the disease is dengue disease.