In HCC, the expression levels of SLC7A11, inverted formin 2 (INF2), myosin heavy chain 9 (MYH9), CD2 associated protein (CD2AP), filamon B (FLNB), actinin alpha 4 (ACTN4), capping actin protein of muscle Z-line subunit beta (CAPZB), actin B (ACTB), PDZ and LIM domain 1 (PDLIM1), filamin A (FLNA), myosin light polypeptide 6 (MYL6), talin 1 (TLN1), and destrin (DSTN) were remarkably higher than the normal tissues. This evidence concerns the gene SLC7A11 and hepatocellular carcinoma.