Here, we report a similar finding, Component 1 was significantly lower in HD vaccinees with transient arthritis (GM non-arthritis 0,93 (0,7-0,17) vs GM arthritis 0,34 (-0,05-0,73) p: 0,011) and levels of seven innate plasma biomarkers were also significantly lower (MCP-2, CXCL10, CXCL11, CX3CL1, MCSF, IL-15, OSM), complementary to the four previous biomarkers reported (IL-6, TNF-a, MCP-1 and MIP-1b) (Figure 4B). Here, CX3CL1 is linked to arthritic joint disease.