TRIB3 and neoplasm: Multivariate Cox analysis showed that age (HR=1.028, 95% CI = 1.014 to 1.044, p<0.001], TRIB3 expression (HR=1.267, 95% CI = 1.069 to 1.503, p=0.006), and tumor stage (HR=1.484, 95% CI = 1.232 to 1.787, p<0.001) were all independent prognostic factors for HNSC (Figure 5B).