Interestingly, while the senolytic treatment reduced age-related cardiac fibrosis and macrophage infiltration, neither miR-143/145 deficiency nor premature senescence induced fibrosis or macrophage numbers, suggesting that fibrosis or inflammation are not a major cause of ventricular arrhythmias caused by aging-induced alterations in the miR-145/Sema3a axis. Here, SEMA3A is linked to Ventricular arrhythmia.