INS and diabetes mellitus: The findings revealed that hesperidin and naringin effectively reduced elevated glucose levels, lactate dehydrogenase (LDH), glycated hemoglobin (HbA1C), creatine kinase-myoglobin binding (CK-MB), and aspartate aminotransferase (AST) levels while elevating insulin levels in the blood and boosting glycogen content in the liver and muscles of rats with insulin resistance due to diabetes.