It was found earlier, that the PDK4 inhibition may alleviate some symptoms of type 2 diabetes in mice; in particular, PDK4 deficiency was found to decrease blood glucose and improved glucose tolerance and insulin sensiti-vity in mice with diet-induced obesity (Jeoung and Harris, 2008[27]). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.