BRCA2 and cancer: Other less frequent cancers include leukemia, stomach cancer, and colorectal cancer [200]. Cancers associated with impaired BRCA1 activity include breast, uterine, and ovarian cancer in females, prostate and breast cancer in males, and a modest increase in pancreatic cancer for both males and females [201,202]. The most commonly reported cancers with BRCA2 mutations include pancreas, prostate in males, and melanoma [203].