Additionally, COVID-19 diagnosis in ≥50-year-olds has been associated with an increased risk of developing herpes zoster [114,115]. This apparent controversy might be partially explained by the fine-tuning between acute antiviral immune responses that quickly achieve infection clearance through high IFN secretion and those that lead to longer and more robust inflammatory patterns (i.e., severe forms of COVID-19) with functional exhaustion of IFN responses [116]. The gene discussed is IFNA1; the disease is infection.