A myriad of cancer-associated mutations that disrupt the nuclear targeting of BRCA1 restrict the protein to the cytosol and diminish its nuclear function in homologous recombination repair of DNA breaks [197]. Notably, BRCA1 cytosolic accumulation promotes breast cancer metastasis [198] and independently predicts survival, tumor grade, and recurrence in low-grade basal-like sporadic breast cancers [199]. The gene discussed is BRCA1; the disease is cancer.