Zhang Zhang S. S. The extracellular matrix enriched with membrane metalloendopeptidase and insulin-degrading enzyme suppresses the deposition of amyloid-beta peptide in Alzheimer’s disease cell models The extracellular matrix enriched with membrane metalloendopeptidase and insulin-degrading enzyme suppresses the deposition of amyloid-beta peptide in Alzheimer’s disease cell models . The gene discussed is INS; the disease is early-onset autosomal dominant Alzheimer disease.