Zhou Zhou J. J. Cerebral small vessel disease caused by PLOD3 mutation: Expanding the phenotypic spectrum of lysyl hydroxylase-3 deficiency Cerebral small vessel disease caused by PLOD3 mutation: Expanding the phenotypic spectrum of lysyl hydroxylase-3 deficiency . Here, PLOD3 is linked to hyperinsulinemic hypoglycemia, familial, 4.