TP53 and cancer: To investigate the association between SIRT7 and p53 in cancer prognosis, we initially categorized tumors based on p53 status, classifying them as p53 wild-type (p53WT) or mutant (p53MUT), and we further divided them into two groups based on the median score of SIRT7 mRNA expression: SIRT7 High (SIRT7High) and low (SIRT7Low) expression levels (Figure 3C).