In this study, we found that the expression of autophagy marker LC-3 and autophagy-related facilitators (ULK1, ATG13, and TFEB) was decreased in GC tissues from patients with elevated THADA expression and negatively correlated with THADA, suggesting that THADA in GC cells may be associated with negative regulation of autophagy associated with the mTORC1 signaling pathway. This evidence concerns the gene TFEB and gastric cancer.