Our findings reveal that PHE rich in a wide range of phytocompounds has anti-oxidant and hypoglycemic impact on alloxanized diabetic rats via lowering hyperglycemia-linked oxidative stress via inhibiting the stimulated MAPK downstream JNK pathway and activating the anti-oxidant defense mechanism (Nrf-2/Keap-1 pathway). Here, MAPK8 is linked to Hyperglycemia.