The main cause of recessive retinitis pigmentosa in ethnic Jews is a 354-bp Aluinsertion in the MAK gene encoding serine/threonine proteinkinase that is involved in cell cycle regulation and is important for theregulation of the cilium length and photoreceptor cell survival.CRISPR/Cas9-mediated editing of iPSCs via the HDR approach involving Aluinsertion restored the MAK transcript [29]. The gene discussed is MAK; the disease is Posterior column ataxia - retinitis pigmentosa.