Common recognized characteristics among women with BV and TV are the alteration of vaginal compositions, elevation of vaginal pH, and increase of bacterially produced metabolites such as sialidase, proteases, PLC and PLA2, etc., which degrade the mucus secreted from the cervix and facilitates the HPV virus adhering to and breaching the protective epithelial barrier (16). Here, HSPG2 is linked to bacterial vaginosis.