TRIM63 and neoplasm: As expected, benefits were also observed in the absence of chemotherapy, where the cachexia was minimized by the FOR treatment, which recovered body weight (p <0.05), muscle mass (p < 0.05), and grip force (p < 0.01) caused by the presence of the tumor (Supplementary Figures S1A–E), in addition to reducing the gene expression of Trim63 (p < 0.01) and Fbxo32 (p < 0.05) in the skeletal muscle (Supplementary Figure S1F).