SHBG and obesity due to melanocortin 4 receptor deficiency: SHBG was associated inversely with prostate cancer risk in men overall (HRper_SD = 0.918; 95% CI = 0.895 to 0.941), with little evidence for interactions with obesity or diabetes (Figure 2), but with some evidence for an inverse multiplicative interaction with HI (pMI = 0.024) (Figure S2).