SHBG and diabetes mellitus: This showed positive associations of FT with total (15,000 cases), as well as with low grade, and nonaggressive prostate cancer, clearer in normal weight men and stronger in men with diabetes, although an inverse association with SHBG was noted only in the observational and not in the MR analysis and an inverse association with TT was noted in the observational analysis,38 likely influenced by the strong positive association of TT with SHBG, which we have previously described.6