Primary mediastinal (thymic) large B cell lymphoma (sclerosing diffuse large B-cell lymphoma) demonstrates diffuse infiltration of mediastinal soft tissue and surrounding structures with atypical B cells therefore the CD20 and or CD79a markers should be positive.11 Nodular sclerosis variant of Hodgkin disease histologically represents sclerotic lesions with nodules of eosinophils and histiocytes admixed with lymphocytes and plasma cells. This evidence concerns the gene CD79A and diffuse large B-cell lymphoma.