PPARA and myeloid sarcoma: However, no clear link with MS pathology can be drawn for LTB4–PPAR-α signaling considering that EAE progression and severity in PPAR-α KO EAE mice was similar to that of WT EAE mice, and PPAR-α protein levels, unlike PPAR-γ, are unaltered in the CSF of PwMS [117, 118].