SPRY4 and pulmonary arterial hypertension: For SSc-related PAH, it has been reported that serum levels of anti-centromere antibody (especially the anti-p4.2 antibody subset), anti-vinculin antibody, IL-32, midkine, follistatin-like 3, osteopontin, chemerin, and specific long noncoding RNAs (e.g., ANCR and SPRY4-IT1) are positively correlated with the presence of PAH, whereas serum anti-topoisomerase antibody levels are negatively correlated with the presence of PAH [23–30].