GO analysis of the SSc with PAH group indicated that the processes of peptidyl-tyrosine phosphorylation, peptidyl-tyrosine modification, protein autophosphorylation, leukocyte migration, positive regulation of kinase activity, positive regulation of protein kinase activity, regulation of tissue remodeling, and cell chemotaxis were activated, and the processes of acute-phase response and negative regulation of endopeptidase activity were inhibited (Fig. 1A). This evidence concerns the gene WEE1 and pulmonary arterial hypertension.