METTL3 and central nervous system cancer: As the coding gene, ADAR1 modifications that occur at the mRNA level or protein level can have an impact on its expression, localization, function, etc. In a recent study on glioma, researchers found that RNA methyltransferase-like 3 (METTL3) can target the m6A site near the termination codon of the ADAR1 transcript to regulate ADAR1 protein expression thereby affecting the proliferation of glioma cells [112].