In our study, we aimed to investigate the association between BTLA SNPs and RCC susceptibility in the Polish population, seven BTLA SNPs; rs1844089, rs2705535, rs9288953, rs9288952, rs16859633, rs1982809, and rs2705511 were genotyped in 282 RCC patients and 480 HC. Here, BTLA is linked to renal cell carcinoma.