The fusion of PRKACA and DNAJB1 is dominant and oncogenic in fibrolamellar hepatocellular carcinoma (FLC) [88], while the DNAJB1-PRKACA or ATP1B1-PRKACB fusion is also detected in pancreatobiliary neoplasms [89, 90]. This evidence concerns the gene PRKACA and fibrolamellar hepatocellular carcinoma.