BAP1 and hepatocellular carcinoma: While DNAJB1-PRKACA fusion drives oncogenic pathways and induces FLC [105], the mixed-FLC/HCC tumors with inactivating mutations or translocations in the gene encoding BRCA1-associated protein-1 (BAP1) also harbor a chromosome gain of PRKACA and a loss of the inhibitory regulatory subunit PRKAR2A, thus exhibiting addiction to PKA activation [106].