While mRNAs of genes relating to innate immunity or control of virus infection were not among the top DEG, some genes associated with GO pathways, including Innate Immune Response, Response to Virus, Response to Type 1 Interferon, Response to Interferon Alpha, and Response to Interferon Beta, were differentially expressed between iOSN and mOSN (Fig. 2A). The gene discussed is IFNB1; the disease is viral infectious disease.