Together with our data showing that spleMos were the main Agtr1a expressing cell type in the spleen, that ANGII infusion aggravated subretinal inflammation spleen dependently, and that pharmacological ATR1 blockage inhibited subretinal inflammation, our results strongly argued for an important pathogenic effect of Ly6ChighATR1+spleMo recruitment in the subretinal space. The gene discussed is AGT; the disease is inflammatory response.