One major topic is, case reports suggested that SCLC transformation can also occur after ALK inhibitor treatment [3, 4],PD1/PD-L1 immunotherapy [5], which implies that SCLC transformation is not restricted in EGFR mutant LUAD, while systematic real-world survey with a larger cohort is lacking. The gene discussed is EGFR; the disease is small cell lung carcinoma.