Meanwhile, except for NPC1L1 and HMGCR genes, other lipid regulatory genes like PCSK9, APOB, ABCG5-G8, KCNK5, LDLR, LPA, et al. have also been provided the evidence to their critical role in CHD risk [45], and further investigations on these genes’ SNPs with CAC susceptibility is worthy. The gene discussed is NPC1L1; the disease is coronary artery disorder.