H1 stage (p = 0.03), metastatic grade A (p = 0.002), stromal PD-L1 expression in CRLM (p = 0.003), tumor PD-L1 expression in CRLM (p = 0.004), better differentiation in the primary site (p = 0.001), and shallow tumor invasion in the primary site (p = 0.04) were significant prognostic factors for longer OS. This evidence concerns the gene CD274 and neoplasm.