IL-6 levels increase in the early stage of AIS patients, and when combined with infection, IL-6 and other pro-inflammatory cytokines can be further increased, thus further accelerating the inflammatory response procedure and leading to tissue and cell damage.Kwan suggested that IL-6 may be a key biomarker for predicting stroke associated infection and mortality in the first two years post stroke [24]. This evidence concerns the gene IL6 and stroke disorder.