To elucidate the possible relevance between the SFXN family and LUAD, we conducted an integrative analysis of the SFXN family, particularly SFXN1, through various cancer-related databases such as TCGA, Gene Expression Omnibus (GEO), and Clinical Proteomic Tumor Analysis Consortium (CPTAC), and deeply investigated the relationship between SFXN1 expression and various immune cell infiltrations and clinical drug sensitivity. This evidence concerns the gene SFXN1 and cancer.