By contrast, and consistent with the hypothesis that normal tactile reactivity during development may be predictive of normal anxiety-like and social behaviors in adulthood, the reactivity of Nlgn2- and Rorb-mutant animals to air puffs was indistinguishable from that of control littermates at P4 (Fig. 2c,d and Extended Data Fig. 2g,h). The gene discussed is NLGN2; the disease is Anxiety.