VIM-, NDM-, and IMP-type MBLs are the most common MBL types in CRPA, and infections caused by MBL-producing P. aeruginosa (MBL-PA) are particularly challenging since these enzymes confer resistance to all beta-lactams, including all currently available beta-lactam-beta-lactamase inhibitor (BLBLI) combinations, with the exception of aztreonam (ATM), and the recently approved siderophore antibiotic, cefiderocol (FDC) [7]. This evidence concerns the gene LACTB and infection.