Patients with 2 or more positive nonspecific blood tests (C-reactive protein > 8 mg/L, procalcitonin > 1.0 ng/mL, or white blood cell count ≥ 20×109/L) were considered to have possible bacterial infection, and patients tested positive for sterile sample (neonatal blood, lower respiratory tract samples obtained by tracheal aspirate, or cerebrospinal fluid) cultures were considered to have confirmed bacterial infection. The gene discussed is CRP; the disease is bacterial infectious disease.