Consistent with observations in MM patients [9], an increase of T cell numbers (both CD8+ and CD4+) was seen post-treatment in responders (Fig. 2b), whereas a decrease of T cell numbers was observed post-treatment in nonresponders; in both responders and nonresponders, no significant difference was observed in the CD4/CD8 ratio, as measured by flow cytometry. The gene discussed is CD4; the disease is Miyoshi myopathy.