EZHIP and diffuse midline glioma: In the fifth edition of the World Health Organization (WHO) classification of central nervous system (CNS) tumors, diffuse midline glioma H3 K27-altered is a pediatric-type diffuse high-grade glioma that arises in midline anatomical structures and displays the immunohistochemical loss of H3 trimethylated in lysine 27 (H3 K27me3), in association with H3 K27M mutation, or EZHIP overexpression [1].