Similar to adoptive transfer of ARS2KO OT-I TCR-transduced CD8+ T cells, adoptive transfer of OT-I TCR-transduced CD28AYAA CD8+ T cells failed to control E.G7-OVA tumor growth as well as WT control cells did, while OT-I TCR-transduced CD28Y170F CD8+ T cells demonstrated an antitumor function similar to that of WT control cells (Fig. 2F and Supplementary Fig. 3D). The gene discussed is CD8A; the disease is neoplasm.