We applied the GLIPH2 algorithm to the TCRβ repertoire of total memory CD4+ T cells from patients with GBS (n = 10) and antigen-reactive T cells obtained, respectively, by high-throughput sequencing and scRNA-seq analysis, as well as to published TCRβ datasets of memory CD4+ T cells from healthy donors27–29 (n = 9), including our reference dataset of known PNS-myelin-specific clonotypes obtained from single T cell clones. Here, CD4 is linked to Guillain-Barre syndrome.