This may be advantageous in preventing conditions with an exaggerated inflammatory response, such as the cytokine storm which may be seen in sepsis and is associated with increased mortality.26 However, there may be a reduction in the innate inflammatory response to infection indicating a relative immunosuppression.12 The NLRP3 inflammasome is an essential component of the innate immune system. Here, NLRP3 is linked to infection.