In Tamoxifen-treated MCF7 samples, the downregulation of the JCHAIN and C1RL, which are reported by the Human Protein Atlas database to be associated with favourable outcomes in breast cancer, is of concern; however, IGKV-4, which is favourable in breast cancer, was upregulated (Figs. 3, 4, Supplementary Table 2). The gene discussed is C1RL; the disease is breast carcinoma.