For the negative correlation between sLAG3 concentrations in serum and expression of LAG3 in CD3+ CD8+ or CD3+ CD4+ cells, we deliver encouraging results, but it is based on a small patient cohort (n = 6) and warrants confirmation in larger patient collectives, even with approaches that also take the TME and tumor infiltrating-lymphocytes (TILs) into consideration for better mechanistic comprehension. This evidence concerns the gene CD4 and neoplasm.