While candidate-approach-identified association is often incompletely replicated at the genome-wide level69–71, as noted in Table 8, extension of associations for the top 10 SNPs identified for severe ROP by Hartnett et al. 16 demonstrates independent replication for rs10251365 in the RELN gene (p = 0.009). Here, RELN is linked to retinopathy of prematurity.