A twenty-four-hour exposure to OST-01 resulted in a significantly decreased levels of c-Myc and other nucleolar proteins i.e., NPM1, nucleostemin and nucleolin, (Fig. 1D, E and Fig. S2E) and disruption of the normal nucleolar architecture in HL-60 cells and CD34 + CD38- AML blasts (Fig. 1F and Fig. S2F). Here, CD38 is linked to acute myeloid leukemia.