The three natural products also induce apoptosis in a various of cancers both in vitro and in vivo, including prostate cancer47, hepatocellular carcinoma48, ovarian adenocarcinoma44, and pancreatic cancer cells49, through downregulation of Bcl-2 expression, and up-regulation of Bax and Caspase 3 mRNA. The gene discussed is CASP3; the disease is familial pancreatic carcinoma.