To explore the role of FKBP10 in the activation of the hypoxia pathway, HK2 cells and several ccRCC cell lines (Caki1, AHCN and RCC4) were treated with the hypoxia-mimicking agent CoCl2 (200 μM, 24 h) or exposed to hypoxia for 24 h (1% O2). This evidence concerns the gene FKBP10 and nonpapillary renal cell carcinoma.