Given that in ccRCC cell lines, HIF2α was generally highly expressed while HIF1α had low or no expression, we overexpressed HIF1α in 786 O and Caki1 cells, and found that FKBP10 expression was suppressed at both the mRNA and protein levels (Fig. 7E, F, S6E). This evidence concerns the gene EPAS1 and nonpapillary renal cell carcinoma.