Further analysis of the conditioned media exhibited a marked reduction in interleukin-6 (IL-6) and IL-8 secretion when coculturing CD28KD or CD40LGKD T-ALL cells with HS-5 cells (Fig. 7B), demonstrating alterations in leukemia-infiltrated stromal microenvironment. Here, CXCL8 is linked to acute lymphoblastic leukemia.