RIP-RT-qPCR analysis showed that PLOD2 transcripts were significantly enriched by anti-METTL3 antibody precipitation compared with the IgG pull-down group in RCC cell lines (Fig. 5H, I), confirming the direct interaction between METTL3 and PLOD2 mRNA. The gene discussed is METTL3; the disease is renal cell carcinoma.