LDLR and atherosclerosis: The study did not show any significant differences in plaque formation or pathology between the Sirt3−/− mice and the wild‐type mice on Ldlr−/− background.[24] Meanwhile, these mice showed similar metabolic phenotypes such as more weight gain, compared to C57/BL6 mice without Ldlr−/− on a high‐fat diet.[24] There is no report of Sirt3−/− mice on the Apoe−/− background for atherosclerosis study.